Female Gender Is Associated with Higher Susceptibility of Weight Induced Arterial Stiffening and Rise in Blood Pressure
| Autor: | Revathy Carnagarin, Junli Zuo, Audrey Adji, Huijuan Chao, Janis M. Nolde, Markus P. Schlaich, Alberto Avolio, Biwen Tang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
obesity hypertension pulse wave velocity Pulsatile flow Hemodynamics body mass index Overweight Article Microcirculation Internal medicine medicine Pulse wave velocity business.industry General Medicine medicine.disease Blood pressure arterial stiffness Arterial stiffness Cardiology cardiovascular system Medicine medicine.symptom business Body mass index |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 16 Journal of Clinical Medicine, Vol 10, Iss 3479, p 3479 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10163479 |
| Popis: | Arterial stiffness is an important predictor of cardiovascular events, independent of traditional risk factors. Stiffening of arteries, though an adaptive process to hemodynamic load, results in substantial increase in the pulsatile hemodynamic forces that detrimentally affects the microcirculation perfusing the vital organs such as the brain, heart and kidneys. Studies have proposed that arterial stiffness precedes and may contribute to the development of hypertension in individuals with obesity. Our study sought to determine the gender-based effects on arterial stiffening in obesity which may predispose to the development of hypertension. We found female sex is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure in obesity. Women had significantly higher carotid-femoral pulse wave velocity (CF-PWV) with higher body mass index (BMI) status (normal: 7.9 ± 2 m/s overweight: 9.1 ± 2 m/s obese: 9 ± 2 m/s, p < 0.001), whereas it was similar in males across all BMI categories. The linear association between arterial stiffness and BMI following adjustment for age and brachial systolic and diastolic blood pressure (BP), remained significant in females (β = 0.06 95% CI 0.01 to 0.1 p < 0.05) but not in males (β = 0.04 95% CI −0.01 to 0.1 p > 0.05). The mean CF-PWV values increased by 0.1 m/s for every 1 kg/m2 increase in BMI in the female subjects in the age adjusted linear model, while such effect was not seen in the male subjects. In line with arterial stiffening, the overweight and obese females demonstrated significantly higher systolic brachial BP. (BP difference: ΔBP 9−11 mmHg, p < 0.01) and central systolic pressure (ΔBP 8−10 mmHg, p < 0.05) compared to their lean counterparts, unlike the male subjects. Our results suggest that female gender is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure. |
| Databáze: | OpenAIRE |
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