Estimation of impurity profiles of drugs and related materials. Part 9: HPLC investigation of flumecinol
| Autor: | B. Herényi, S. Görög, M. Rényei |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Flumecinol
Chromatography Chemistry Clinical Biochemistry Analytical chemistry Impurity profiling Pharmaceutical Science Stereoisomerism High-performance liquid chromatography Analyse qualitative Analytical Chemistry Qualitative analysis Impurity Drug Discovery Spectrophotometry Ultraviolet Benzhydryl Compounds Enantiomer Drug Contamination Chromatography High Pressure Liquid Spectroscopy Chiralcel OD |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 10:831-835 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/0731-7085(91)80088-q |
| Popis: | Two HPLC systems have been developed for the investigation of flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol). The reversed-phase system (LiChrosorb RP-18; methanol-water, 7:3, v/v) enables the isolation and identification of the impurities. The chiral system (Chiralcel OD; hexane-2-propanol, 98:2, v/v) separates the enantiomers of flumecinol and its impurities. The potential of spectral convolution in peak identification in HPLC impurity profiling is demonstrated by an example involving the identification of the 4'-methyl-analogue of flumecinol. |
| Databáze: | OpenAIRE |
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