Opium-Related Lead Toxicity: An Integrative Review and Case Series
| Autor: | Maryam Bahreini, Ali Tafazoli Moghadam, Babak Choobi Anzali |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Poison control Opium 01 natural sciences Lead poisoning Drug user 03 medical and health sciences 0302 clinical medicine Injury prevention medicine Humans 030212 general & internal medicine 0101 mathematics Medical diagnosis Disease management (health) Intensive care medicine education education.field_of_study business.industry 010102 general mathematics Human factors and ergonomics Opioid-Related Disorders medicine.disease Analgesics Opioid Lead Poisoning Lead Emergency Medicine business |
| Zdroj: | The Journal of Emergency Medicine. 59:33-45 |
| ISSN: | 0736-4679 |
| Popis: | Background Restrictive regulations and the increased price of opioids have resulted in the addition of impurities to illicit opioids by drug dealers. Among the adulterants, lead salts are optimal agents to make packages heavier. Consequently, lead toxicity has emerged in the opioid-user population. Objectives Our goal was to review the related literature and describe patients with common presentations of opioid-related lead poisoning to provide a basis to prepare optimal management. Methods A narrative review was performed aiming to study opioid lead poisoning. PubMed and Google Scholar databases were explored with two Medical Subject Heading terms, lead poisoning and substance-related disorders to find a broad but relevant spectrum of articles. Then, the reference lists within those articles were checked to upgrade our literature pool on this issue. Results Ultimately, among English-language articles, 16 were case series and case reports of patients with lead intoxication after opioid consumption. Data pertaining to disease characteristics, diagnosis, and treatment protocols were extracted. Conclusions The clinical presentation of opioid lead intoxication can vary from rather asymptomatic to severely debilitating gastrointestinal or neurologic symptoms. The diagnosis is made by checking lead blood levels after obviating other critical diagnoses and should be considered in each drug user in endemic regions of opioid addiction, such as the Middle East. Management protocols are suggested to cover both features of opioid-related complications and lead toxicity. |
| Databáze: | OpenAIRE |
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