Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti‐Inflammatory Activity

Autor: Ying Liu, Wanqiu Liu, Siqi Fan, Yuanyuan Yu, Zhaoxia Shi, Wenyuan Liu, Zongyao Wu, Yuzhi Jiao, Huiling Tang, Jie Zhang, Lijun Xu, Feng Feng, Jian Xu
Rok vydání: 2023
Předmět:
Zdroj: Chemistry & Biodiversity. 20
ISSN: 1612-1880
1612-1872
DOI: 10.1002/cbdv.202200822
Popis: The traditional Chinese medicine of fermented medicine may be under the involvement of multiple strains and the interaction between these microorganisms. Liu Shenqu (Massa Medicata Fermentata, MMF) is one of the most widely used fermented medicines, whose potential processing mechanism is still unclear. In this work, UPLC/MS and GNPS methods were employed to rapidly predict chemical compositions in MMF. Moreover, the dynamic changes of strains, chemical compositions and anti-inflammatory activity of MMF during fermentation process were investigated, and subsequently strains-chemical compositions-efficacy interactions were revealed by Pearson correlation analysis and partial least squares regression (PLSR) analysis. As a result, 24 components were identified, and the potential strains including Bacillus, Burkholderia_Caballeronia_Paraburkholderia, Enterobacter, Aspergillus heterocaryoticus, Rhizopus arrhizus, Kazachstania bulderi, which related to the production of anti-inflammatory active ingredients were exposed. These results demonstrated chemical compositions-strains-efficacy interactions during fermentation of MMF, and provide reference for the exploration of the processing mechanism of MMF.
Databáze: OpenAIRE
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