Measurement of patient-relevant benefits in the treatment of chronic hand eczema - a novel approach
Autor: | Thomas L. Diepgen, Christine Blome, Matthias Augustin, J. Maares, Stephan Jeffrustenbach |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Eczema Hand Dermatoses Dermatology Alitretinoin Cost of Illness Quality of life Cronbach's alpha Germany Surveys and Questionnaires Outcome Assessment Health Care Humans Immunology and Allergy Medicine In patient Disease burden Aged business.industry Reproducibility of Results Middle Aged Convergent validity Patient Satisfaction Chronic Disease Chronic hand eczema Quality of Life Physical therapy Feasibility Studies Female Outcomes research business Needs Assessment medicine.drug |
Zdroj: | Contact Dermatitis. 61:39-45 |
ISSN: | 1600-0536 0105-1873 |
Popis: | Background: The assessment of patient-relevant treatment benefit gains importance in treatment evaluation. The ‘Patient Benefit Index’ (PBI) is a validated instrument for the assessment of such benefits in patients with skin diseases. Patients rate the importance of specific treatment needs before treatment and benefits achieved after treatment. To date, no specific instrument for chronic hand eczema (CHE) has been published. Objectives: Development and validation of a specific PBI for treatment evaluation in patients with CHE. Methods: Items reflecting disease burden and treatment needs were collected in 20 patients with CHE. Relevant items were selected by an expert panel of dermatologists, psychologists, and patients. The resulting ‘Patient Benefit Index for chronic hand eczema’ (PBI-HE) was validated in an open label treatment study with alitretinoin in n = 249 patients. Results: Cronbach’s alpha was 0.93. High convergent validity was demonstrated for clinical improvement and treatment success (Spearman r = 0.60–0.78, P |
Databáze: | OpenAIRE |
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