Effect of trypan blue staining on the elastic modulus of anterior lens capsules of diabetic and nondiabetic patients
| Autor: | Jessica D. Kaufman, Paul A. Legutko, Mary K. Daly, Maria Stephanie R Jardeleza, Catherine M. Klapperich |
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| Rok vydání: | 2008 |
| Předmět: |
Anterior lens
Adult medicine.medical_specialty Aging medicine.medical_treatment Lens Capsule Crystalline Trypan blue staining Cataract chemistry.chemical_compound Anterior Eye Segment Diabetes mellitus Ophthalmology Elastic Modulus otorhinolaryngologic diseases Diabetes Mellitus Medicine Humans Prospective Studies Coloring Agents Capsulorhexis Glycated Hemoglobin Staining and Labeling business.industry Capsule Trypan Blue Cataract surgery medicine.disease Sensory Systems Biomechanical Phenomena stomatognathic diseases medicine.anatomical_structure chemistry Lens (anatomy) Surgery Trypan blue business |
| Zdroj: | Journal of cataract and refractive surgery. 35(2) |
| ISSN: | 1873-4502 |
| Popis: | Purpose To determine whether trypan blue causes a significant difference in the biomechanical properties (stiffness) of diabetic and nondiabetic anterior lens capsules and to determine whether diabetes significantly alters the stiffness of anterior lens capsules. Setting Veterans Administration Boston Healthcare Center System, Jamaica Plain, Massachusetts, USA. Methods In this unmasked prospective randomized controlled experimental study, anterior lens capsules were obtained from diabetic and nondiabetic patients approved for cataract surgery. Four treatment groups were created: (1) capsules of nondiabetic patients without trypan blue; capsules of nondiabetic patients with trypan blue; (3) capsules of diabetic patients without trypan blue; (4) capsules of diabetic patients with trypan blue. Anterior lens capsule stiffness as a function of elastic (Young's) modulus (kilopascals) was measured with the Hysitron TriboIndenter. Results The use of trypan blue led to significantly stiffer anterior lens capsules (P = .036). Trypan blue had the greatest effect on the stiffness of diabetic lens capsules (P = .046). Conclusion Trypan blue contributed to increased capsule stiffness during capsulorhexis, especially in diabetic patients. |
| Databáze: | OpenAIRE |
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