Drug-Induced Urolithiasis in Pediatric Patients
| Autor: | S. Ciarlariello, Giampaolo Bianchi, Stefano Puliatti, V. Durante, Ahmed Zoeir, Bernardo Rocco, Ahmed Eissa, Maria Chiara Sighinolfi, Pier Luca Ceccarelli, Salvatore Micali, Elena Morini, L. Bevilacqua |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
Adult medicine.medical_specialty Adolescent media_common.quotation_subject Urinary system Child Child Preschool Humans Infant Infant Newborn Kidney Calculi Risk Factors Urolithiasis Young Adult urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Pharmacotherapy 030225 pediatrics Medicine Pharmacology (medical) Medical history Young adult Intensive care medicine Preschool media_common business.industry Mechanism (biology) Newborn female genital diseases and pregnancy complications Metabolic effects Pediatrics Perinatology and Child Health Drug consumption business 030217 neurology & neurosurgery |
| Popis: | Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient's history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi. |
| Databáze: | OpenAIRE |
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