Congenital astroblastoma: an immunohistochemical study
| Autor: | David Webb, Hugh B. Coakham, Anthony Oakhill, Barry L. Pizer, Tim H. Moss |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Vincristine Pathology medicine.medical_specialty Cell Adhesion Molecules Neuronal medicine.medical_treatment Astroblastoma Receptors Lymphocyte Homing Receptors Cell Surface Glial tumor Astrocytoma Central nervous system disease medicine Humans Neoplasm Etoposide Chemotherapy Brain Neoplasms business.industry S100 Proteins Infant Newborn medicine.disease Combined Modality Therapy Natural history Microscopy Electron Hyaluronan Receptors Phosphopyruvate Hydratase Carrier Proteins business medicine.drug |
| Zdroj: | Journal of Neurosurgery. 83:550-555 |
| ISSN: | 0022-3085 |
| DOI: | 10.3171/jns.1995.83.3.0550 |
| Popis: | ✓ Astroblastoma is a rare type of glial tumor, usually occurring in older children and young adults. It has a distinctive histological appearance that is characterized by a radiating arrangement of tumor cells that form perivascular pseudorosettes. The authors report only the second case of astroblastoma presenting in congenital form. Following subtotal tumor resection, the infant received 10 courses of chemotherapy consisting of vincristine, etoposide, and carboplatinum. Evidence is presented for a tumor response to chemotherapy, a previously unreported observation. The child is alive 2.5 years after diagnosis with satisfactory functional status. Immunohistological and ultrastructural features of this tumor are presented. The discussion focuses on the biology, natural history, and management of this unusual neoplasm. |
| Databáze: | OpenAIRE |
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