IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR‐Src‐MicroRNA-30a‐E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells
| Autor: | Heming Li, Wang Zhe, Xuefen Guo, Ruoyu Wang, Shanshan Liang, Chengxue Dang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition (EMT) medicine.medical_treatment MicroRNA-30a (miR-30a) Biology Article Receptor IGF Type 1 Metastasis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor otorhinolaryngologic diseases medicine Carcinoma Humans Epithelial–mesenchymal transition Insulin-Like Growth Factor I Insulin-like growth factor I receptor (IGF-IR) Nasopharyngeal Carcinoma Cadherin Growth factor Nasopharyngeal Neoplasms Receptors Somatomedin General Medicine Cadherins medicine.disease MicroRNAs stomatognathic diseases src-Family Kinases 030104 developmental biology Oncology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Cancer research Insulin-like growth factor I (IGF-I) Signal transduction Src Signal Transduction Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Oncology Research |
| ISSN: | 0965-0407 |
| DOI: | 10.3727/096504016x14648701447931 |
| Popis: | Recurrence and distant metastasis are the most common cause of therapeutic failure in nasopharyngeal carcinoma (NPC) patients. Insulin-like growth factor I (IGF-I) can induce epithelial-to-mesenchymal transition (EMT) in many epithelial tumors; however, whether IGF-I can enhance NPC metastasis by EMT and the mechanisms remain unclear. Herein, we have identified that IGF-I could induce EMT and enhance migration ability in NPC cell lines. Furthermore, both Src inhibitor and microRNA-30a (miR-30a) inhibitor reversed IGF-I-induced EMT, suggesting the involvement of an IGF-IR‐Src‐miR-30a‐E-cadherin pathway in IGF-I-induced EMT in NPC cell lines. Overall, the results of the present study may provide more useful information regarding the mechanisms of the IGF-IR signaling pathway in the regulation of NPC metastasis. Both Src kinase and miR-30a can be potential biomarkers for selecting high risk of metastasis in NPC patients. |
| Databáze: | OpenAIRE |
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