The discovery of long acting β2-adrenoreceptor agonists

Autor:	Charlotte Alice Louise Lane, Mike Trevethick, Russell Andrew Lewthwaite, Kim James, Christelle Perros-Huguet, Mark E. Bunnage, Rhys M. Jones, Paul Alan Glossop, David Price, Rob Webster, Simon John Mantell, Alan Daniel Brown
Rok vydání:	2007
Předmět:	Agonist medicine.medical_specialty medicine.drug_class Clinical Biochemistry Pharmaceutical Science Biochemistry β2 adrenergic receptor Mice Internal medicine Drug Discovery medicine Animals Humans Molecular Biology Chemistry Tissue Model Organic Chemistry Adrenergic beta-Agonists Long acting Endocrinology Adrenergic beta-1 Receptor Agonists Benzene derivatives Molecular Medicine Salmeterol Formoterol Caco-2 Cells Once daily medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:4012-4015
ISSN:	0960-894X
Popis:	The design and profile of a series of saligenin containing long acting β2-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5220dac31d5223846ee0063a0531ad90 https://doi.org/10.1016/j.bmcl.2007.04.081 Zobrazit plný text záznamu Full Text from ScienceDirect