Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans

Autor: Diego R. Mazzotti, Camila Guindalini, Juliana C. Perry, Sergio Tufik, Silverio Garbuio, Lia Bittencourt
Rok vydání: 2013
Předmět:
Male
Pulmonary and Respiratory Medicine
Oncology
medicine.medical_specialty
Physiology
Polysomnography
medicine.medical_treatment
Body Mass Index
stomatognathic system
Internal medicine
medicine
Humans
Gene Regulatory Networks
RNA
Messenger
Continuous positive airway pressure
Genetic Association Studies
Oligonucleotide Array Sequence Analysis
Whole blood
Analysis of Variance
Sleep Apnea
Obstructive
Continuous Positive Airway Pressure
medicine.diagnostic_test
Procollagen-Lysine
2-Oxoglutarate 5-Dioxygenase
business.industry
Gene Expression Profiling
General Neuroscience
Sleep apnea
Hypoxia (medical)
medicine.disease
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
Gene Expression Regulation
Anesthesia
Female
medicine.symptom
Carrier Proteins
business
Hypopnea
Body mass index
Zdroj: Respiratory Physiology & Neurobiology. 189:649-654
ISSN: 1569-9048
Popis: In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patients were assigned to participate in a continuous positive airway pressure (CPAP) protocol for 6 months. Blood was collected and the expression of 84 genes analyzed using the RT(2) Profiler™ PCR array. Mild-to-moderate OSA patients demonstrated down-regulation of 2 genes associated with induction of apoptosis, while a total of 13 genes were identified in severe OSA patients. After controlling for body mass index, PRPF40A and PLOD3 gene expressions were strongly and independently associated with AHI scores. This research protocol highlights a number of molecular targets that might help the development of novel therapeutic strategies.
Databáze: OpenAIRE
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