High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension
| Autor: | Katsanou Pm, C V Vassilopoulos, M E Fotia, E J Diamantopoulos, Marakomichelakis Ge, G I Tsourous, Emmanuel A. Andreadis |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Ambulatory blood pressure Combination therapy media_common.quotation_subject Urology Blood Pressure Essential hypertension Severity of Illness Index Renin–angiotensin system Internal Medicine Humans Medicine Aged media_common Dose-Response Relationship Drug business.industry Dihydropyridine Blood Pressure Monitoring Ambulatory Middle Aged Calcium Channel Blockers medicine.disease Surgery Blood pressure Hypertension Ambulatory Drug Therapy Combination Female business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | Journal of Human Hypertension. 19:491-496 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1001843 |
| Popis: | The objectives of the study were to compare long-acting dihydropyridine calcium channel blockers (CCBs) with angiotensin II receptor blockers (ARBs) according to the ambulatory blood pressure monitoring (ABPM) profile in stage 1 and 2 newly diagnosed hypertensives and also to evaluate the efficacy of high-dose monotherapy vs low-dose combination therapy of the two drug categories among the subjects with inadequate blood pressure (BP) control after conventional low-dose monotherapy. We obtained 24-h ABPM readings from 302 subjects with newly diagnosed stage 1 or 2 essential hypertension. The study protocol consisted of initial drug treatment with a low dose of either CCBs or ARBs. Hypertensives who did not achieve BP control were randomized to high-dose monotherapy of either category of drug or low-dose combination therapy. CCBs and ARBs in low-dose monotherapy achieved BP control in 53.8 and 55.3% of the cases, respectively. However, subjects under treatment with CCBs experienced side effects more often and required that treatment be discontinued. Hypertensives who failed to control their BP with low-dose monotherapy did significantly better with low-dose combination treatment (61.6%) than with high-dose CCBs (42.8%) or ARBs (40.5%) monotherapy (P |
| Databáze: | OpenAIRE |
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