Evaluation of vitamin D receptor expression in uterine leiomyoma and nonneoplastic myometrial tissue: a cross‐sectional controlled study
| Autor: | Pedro Vitor Lopes Costa, Alesse Ribeiro dos Santos, Maria Simone Oliveira Lima, Menandro Lima de Medeiros, Walberto Monteiro Neiva Eulálio Filho, Emerson Davi do Nascimento Brazil, Benedito Borges da Silva, Antônio Gilberto Albuquerque Brito, Jerusia Oliveira Ibiapina |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Infertility Pathology medicine.medical_specialty QH471-489 medicine.medical_treatment Nutritional Status Calcitriol receptor Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Humans Medicine Reproductive History 030219 obstetrics & reproductive medicine Uterine leiomyoma Hysterectomy Leiomyoma business.industry Research Reproduction Nonneoplastic myometrium Obstetrics and Gynecology Myoma Gynecology and obstetrics Middle Aged medicine.disease Immunohistochemistry Neoplasm Proteins Tumor Burden Cross-Sectional Studies 030104 developmental biology Reproductive Medicine Vitamin D receptor Uterine Neoplasms Myometrium RG1-991 Etiology Receptors Calcitriol Female business Developmental Biology |
| Zdroj: | Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-6 (2021) Reproductive Biology and Endocrinology : RB&E |
| ISSN: | 1477-7827 |
| Popis: | Background Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Some studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas. This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue. Methods A controlled cross-sectional study involving 40 women who underwent abdominal hysterectomy the Department of Gynecology of the Getúlio Vargas Hospital of Federal University of Piauí, Brazil, was performed to compare the immunohistochemical expression of VDR in samples of uterine leiomyoma tissue with adjacent nonneoplastic myometrial tissue. The mean percetages of stained nuclei in the two groups was compared by Student’s t teste, with significance established at p Results The percentage of cells with nuclei stained by anti-VDR in the myometrial and leiomyoma tissue was 79.52 % (± 4.32) and 60.22 % (± 7.24), respectively (p Conclusions The mean percentage of nuclei expressing VDR was significantly lower in the uterine leiomyoma than in nonneoplastic myometrial tissue. |
| Databáze: | OpenAIRE |
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