Ethnicity modifies the relation between fasting plasma glucose and HbA 1c in Indians, Malays and Chinese
| Autor: | Jeannette Lee, Kavita Venkataraman, Agus Salim, S. L. Kao, E-Shyong Tai, A. C. Thai, E. Y. H. Khoo, Derrick Heng |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male China medicine.medical_specialty endocrine system diseases diagnosis Endocrinology Diabetes and Metabolism Ethnic group India White People chemistry.chemical_compound Endocrinology Insulin resistance Asian People Predictive Value of Tests Risk Factors Surveys and Questionnaires Diabetes mellitus Internal medicine Internal Medicine medicine Humans glycated haemoglobin Article: Epidemiology Glycated haemoglobin Triglycerides Singapore Plasma glucose Cholesterol business.industry Malaysia nutritional and metabolic diseases Fasting Original Articles Middle Aged medicine.disease Diabetes Mellitus Type 2 chemistry Predictive value of tests diabetes mellitus ethnicity Female Insulin Resistance Waist Circumference business |
| Zdroj: | Diabetic Medicine |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2012.03599.x |
| Popis: | Aims To study whether HbA1c, and its relationship with fasting plasma glucose, was significantly different among Chinese, Malays and Indians in Singapore. Methods A sample of 3895 individuals without known diabetes underwent detailed interview and health examination, including anthropometric and biochemical evaluation, between 2004 and 2007. Pearson’s correlation, analysis of variance and multiple linear regression analyses were used to examine the influence of ethnicity on HbA1c. Results As fasting plasma glucose increased, HbA1c increased more in Malays and Indians compared with Chinese after adjustment for age, gender, waist circumference, serum cholesterol, serum triglyceride and homeostasis model assessment of insulin resistance (P-interaction < 0.001). This translates to an HbA1c difference of 1.1 mmol/mol (0.1%, Indians vs. Chinese), and 0.9 mmol/mol (0.08%, Malays vs. Chinese) at fasting plasma glucose 5.6 mmol/l (the American Diabetes Association criterion for impaired fasting glycaemia); and 2.1 mmol/mol (0.19%, Indians vs. Chinese) and 2.6 mmol/mol (0.24%, Malays vs. Chinese) at fasting plasma glucose 7.0 mmol/l, the diagnostic criterion for diabetes mellitus. Conclusions Using HbA1c in place of fasting plasma glucose will reclassify different proportions of the population in different ethnic groups. This may have implications in interpretation of HbA1c results across ethnic groups and the use of HbA1c for diagnosing diabetes mellitus. |
| Databáze: | OpenAIRE |
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