Impact of vaccines on antimicrobial resistance
Autor: | Philippe Buchy, Sanjoy Datta, Sibel Ascioglu, Sirenda Vong, Michael D. Nissen, Yves Buisson, Paul A. Tambyah |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty medicine.drug_class 030106 microbiology Antibiotics Inappropriate Prescribing lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Bacterial Global health Infection control Medicine Animals Humans lcsh:RC109-216 030212 general & internal medicine Antibiotic use Intensive care medicine Bacteria business.industry General Medicine Bacterial Infections Anti-Bacterial Agents Infectious Diseases Bacterial Vaccines Antibiotic Stewardship business |
Zdroj: | International Journal of Infectious Diseases, Vol 90, Iss, Pp 188-196 (2020) |
ISSN: | 1878-3511 |
Popis: | Drivers of antimicrobial resistance: Antibiotic use drives the development and spread of resistant bacterial infections. Antimicrobial resistance (AMR) has become a prolific global issue, due to significant increases in antibiotic use in humans, livestock and agriculture, inappropriate use (under-dosing and over-prescribing), and misuse of antibiotics (for viral infections where they are ineffective). Fewer new antibiotics are being developed. The problem of AMR: AMR is now considered a key threat to global health, leading to more mortality and increased healthcare costs threatening future conduct of routine medical procedures. Traditional approaches to address AMR include antibiotic stewardship, better hygiene/infection control, promoting antibiotic research and development, and restricting use for agricultural purposes. Vaccines as a tool to reduce AMR: While antibiotic development is declining, vaccine technology is growing. This review shows how vaccines can decrease AMR by preventing bacterial and viral infections, thereby reducing the use/misuse of antibiotics, and by preventing antibiotic-resistant infections. Vaccines are less likely to induce resistance. Some future uses and developments of vaccines are also discussed. Conclusions: Vaccines, along with other approaches, can help reduce AMR by preventing (resistant) infections and reducing antibiotic use. Industry and governments must focus on the development of novel vaccines and drugs against resistant infections to successfully reduce AMR. A graphical abstract is available online. Keywords: Antimicrobial resistance, Vaccine, Antibiotic |
Databáze: | OpenAIRE |
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