Comparison of the effects of nimesulide and 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) on contractions of isolated pregnant human myometrium
| Autor: | Meral Cetin, Baris Karadas, Tijen Kaya, Tevfik Guvenal, Iclal Divrik, Ali Cetin |
|---|---|
| Přispěvatelé: | Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Sivas, Turkey, Cetin, Ali -- 0000-0002-5767-7894 |
| Rok vydání: | 2004 |
| Předmět: |
myometrial smooth muscle
Adult endocrine system medicine.medical_specialty Contraction (grammar) Human myometrium Uterus In Vitro Techniques Dinoprost Oxytocin nimesulide DFU Potassium Chloride Uterine Contraction Pregnancy Internal medicine medicine Humans Cyclooxygenase Inhibitors Furans Sulfonamides Cyclooxygenase 2 Inhibitors biology Cesarean Section business.industry Myometrium Membrane Proteins Obstetrics and Gynecology Isoenzymes Endocrinology medicine.anatomical_structure Reproductive Medicine Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Enzyme inhibitor In utero biology.protein Female business hormones hormone substitutes and hormone antagonists medicine.drug Nimesulide |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 113:172-177 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2003.06.010 |
| Popis: | WOS: 000220945100010 PubMed ID: 15063955 Objective: To compare the effects of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) and nimesulide, selective COX-2 inhibitors, on the amplitude and frequency of KCI-, oxytocin-, and PGF(2alpha)-stimulated contractions of isolated pregnant human myometrial strips. Methods: Isolated myometrial strips were obtained from 20 pregnant women undergoing elective cesarean section. These strips were mounted in organ baths for recording of isometric tension. The effects of cumulative concentrations of nimesulide and DFU on KCl-, oxytocin-, and PGF(2alpha)-stimulated myometrial contractions were measured, and values for -log(10) EC50 and mean maximal inhibition (E-max) were compared. Nimesulide (10(-8) to 10(-4) M) and DFU (10(-8) to 10(-4) M) inhibited in a concentration-dependent manner the KCl-, oxytocin-, and PGF(2alpha)-stimulated contractions of myometrial strips, with a significant effect on the amplitude (10(-7) to 10(-4) M) and the frequency (10(-6) to 10(-4) M). Results: The inhibitor effect of DFU was more potent than nimesulide on KCl-, oxytocin-, and PGF(2alpha)-stimulated myometrial contractions, however, the inhibitor effects of nimesulide and DFU was much greater on KCl-stimulated contractions than on oxytocin- and PGF(2alpha)-stimulated myometrial contractions (P < 0.05). There was no significant difference between E-max values of nimesulide and DFU in all tissues (P > 0.05). Conclusion: DFU is a more potent inhibitor than nimesulide on KCl-, oxytocin-, and PGF(2alpha)-stimulated contractions of pregnant human myometrium. The inhibitor effects of nimesulide and DFU were predominantly on KCl-stimulated contractions. (C) 2003 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect