Levels of Interleukin 27 and Interleukin 35 in the Serum and Vitreous of Patients with Proliferative Diabetic Retinopathy
| Autor: | Ai Yan, Xuedong Zhang, Hui You |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Retinal Neovascularization Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Immunology and Allergy Interleukin 27 Aged Glycated Hemoglobin Diabetic Retinopathy business.industry Interleukins Diabetic retinopathy Middle Aged medicine.disease Vitreous Body Ophthalmology 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Interleukin 35 Female Epiretinal membrane business 030215 immunology Retinopathy |
| Zdroj: | Ocular Immunology and Inflammation. 26:273-279 |
| ISSN: | 1744-5078 0927-3948 |
| Popis: | To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR).Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Patients with idiopathic macular epiretinal membrane (IMEM) were included as a control group. The serum and vitreous levels of IL-27 and IL-35 were measured using ELISA.The serum levels of IL-27 (median 240.900 pg/mL, range 42.224 - 617.810 pg/mL; p0.001) and IL-35 (median 11.875 ng/mL, range 8.640 - 19.340 ng/mL; p0.001) were significantly decreased in PDR patients compared to controls (median 2712.310 pg/mL, range 1005.375-5786.877 pg/mL and median 25.185 ng/mL, range 22.845 - 29.590 ng/mL, respectively). The vitreous levels of IL-35 were significantly decreased in PDR patients (16.32 ± 3.24 ng/mL) compared to controls (24.54 ± 5.86 ng/mL, p0.001).Serum and vitreous levels of IL-35 and serum level of IL-27 may be associated with the pathogenesis of PDR. |
| Databáze: | OpenAIRE |
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