Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system
| Autor: | John T. Green, Meghan C. Eddy, Katherine J. Stansfield |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Striatal dopamine
Male Cognitive Neuroscience Dopamine Motor Activity Brief Communication Task (project management) Cellular and Molecular Neuroscience Executive Function Dopamine receptor D2 Physical Conditioning Animal Animals Discrimination learning Rats Wistar Receptors Dopamine D2 Receptors Dopamine D1 Antagonist technology industry and agriculture Benzazepines Corpus Striatum Dopamine D2 Receptor Antagonists Neuropsychology and Physiological Psychology Dopamine receptor Turnover Facilitation Psychology Neuroscience Psychomotor Performance |
| Zdroj: | Learningmemory (Cold Spring Harbor, N.Y.). 21(7) |
| ISSN: | 1549-5485 |
| Popis: | We have previously demonstrated that voluntary exercise facilitates discrimination learning in a modified T-maze. There is evidence implicating the dorsolateral striatum (DLS) as the substrate for this task. The present experiments examined whether changes in DLS dopamine receptors might underlie the exercise-associated facilitation. Infusing a D1R antagonist into the DLS prior to discrimination learning facilitated the performance of nonexercising rats but not exercising rats. Infusing a D2R antagonist impaired the performance of exercising rats but not nonexercising rats. Exercise-associated facilitation of this task may rely on an exercise-induced decrease in D1R and increase in D2R activation in the DLS. |
| Databáze: | OpenAIRE |
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