Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults
| Autor: | Jordan F. Karp, Marcos Sanches, Benoit H. Mulsant, Rafae Wathra, Kyle W Goldberger, Charles F. Reynolds, Lauren Thomson, Eric J. Lenze, Daniel M. Blumberger |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Venlafaxine 030204 cardiovascular system & hematology Article Norepinephrine (medication) Hypotension Orthostatic 03 medical and health sciences Orthostatic vital signs 0302 clinical medicine Heart Rate Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Serotonin and Noradrenaline Reuptake Inhibitors Depression (differential diagnoses) Aged Aged 80 and over Pharmacology Depressive Disorder Major Dose-Response Relationship Drug business.industry Venlafaxine Hydrochloride Middle Aged Psychiatry and Mental health Hypertension Cardiology Accidental Falls Female Serotonin business Reuptake inhibitor 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | J Psychopharmacol |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881120944154 |
| Popis: | Background: Venlafaxine, a serotonin–norepinephrine reuptake inhibitor, is often used as first- or second-line therapy for depression in older adults. It can be associated with adverse blood pressure (BP) effects. Methods: Adults ⩾60 years of age in a current major depressive episode were treated in a protocolized manner with venlafaxine XR; 429 participants were treated for 8–16 weeks with a daily dose up to 300 mg to achieve remission from depression. Cardiac measures included sitting and standing BP and heart rate. Results: Of participants who were normotensive at baseline, 6.5% were found to have elevated BP during the study (1.9% Conclusion: A large proportion of older adults treated with venlafaxine experience orthostatic hypotension, putting them at risk for falls. A smaller proportion experience elevated BP. Older patients prescribed venlafaxine, particularly at high doses, should be advised and counseled about these adverse effects. |
| Databáze: | OpenAIRE |
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