Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans

Autor: Peter S. Friedmann, Mark D. Ward, Neil P. Walsh, Andrew W. Macfarlane, Adam D. Harper Smith, Sarah L. Coakley
Rok vydání: 2011
Předmět:
Zdroj: Brain, Behavior, and Immunity. 25:1136-1142
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2011.02.014
Popis: Little is known about the influence of exercise on induction and elicitation phases of in vivo immunity in humans. We used experimental contact-hypersensitivity, a clinically relevant in vivo measure of T cell-mediated immunity, to investigate the effects of exercise on induction and elicitation phases of immune responses to a novel antigen. The effects of 2 h-moderate-intensity-exercise upon the induction (Study One) and elicitation of in vivo immune memory (Study Two) to diphenylcyclopropenone (DPCP) were examined. Study One: matched, healthy males were randomly-assigned to exercise (N=16) or control (N=16) and received a primary DPCP exposure (sensitization), 20 min after either 2 h running at 60% V O(2peak) (EX) or 2 h seated rest (CON). Four weeks later, participants received a low, dose-series DPCP challenge (elicitation) on their upper inner arm, which was read at 24 and 48 h as clinical score, oedema (skinfold thickness) and redness (erythema). Study Two: pilot; 13 healthy males were sensitized to DPCP. Elicitation challenges were repeated every 4 weeks until responses reached a reproducible plateau. Then, N=9 from the pilot study completed both EX and CON trials in a randomized order. Elicitation challenges were applied and evaluated as in Study One. Results demonstrate that exercise-induced stress significantly impairs both the induction (oedema -53% at 48 h; P
Databáze: OpenAIRE
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