An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
| Autor: | Guillermo Mariño, Frank Madeo, Lorenzo Galluzzi, Shensi Shen, Isabelle Martins, Alexander Valent, Bastien Job, Mark J. Smyth, Maria Castedo, Gian Maria Fimia, Mickaël Michaud, Francesco Berardinelli, Claire Pailleret, Alfredo Criollo, Vladimir Lazar, Santiago Rello-Varona, Guillaume Pourcher, Mauro Piacentini, Antonella Sistigu, Vichnou Poirier-Colame, Laura Senovilla, Sylvain Ladoire, Ming Li, Sandy Adjemian, Clara Locher, Ilio Vitale, Takahiro Yamazaki, Christoph Ruckenstuhl, Josef M. Penninger, Monique Talbot, Nicole L Messina, Antonio Antoccia, François Ghiringhelli, Verena Sigl, Fabiola Ciccosanti, Guido Kroemer, Mireia Niso-Santano, Maximilien Tailler, Oliver Kepp, Laurence Zitvogel, Alice Boilève, Carlos López-Otín, Didac Carmona-Gutierrez, Christopher J. Chan, Antonio Fueyo |
|---|---|
| Přispěvatelé: | Senovilla, L, Vitale, I, Martins, I, Tailler, M, Pailleret, C, Michaud, M, Galluzzi, L, Adjemian, S, Kepp, O, NISO SANTANO, M, Shen, S, Mariño, G, Criollo, A, Boilève, A, Job, B, Ladoire, S, Ghiringhelli, F, Sistigu, A, Yamazaki, T, RELLO VARONA, S, Locher, C, POIRIER COLAME, V, Talbot, M, Valent, A, Berardinelli, Francesco, Antoccia, Antonio, Ciccosanti, F, Fimia, Gm, Piacentini, M, Fueyo, A, Messina, Nl, Li, M, Chan, Cj, Sigl, V, Pourcher, G, Ruckenstuhl, C, CARMONA GUTIERREZ, D, Lazar, V, Penninger, Jm, Madeo, F, LÓPEZ OTÍN, C, Smyth, Mj, Zitvogel, L, Castedo, M, Kroemer, G., Senovilla, Laura, Vitale, Ilio, Martins, Isabelle, Tailler, Maximilien, Pailleret, Claire, Michaud, Mickaël, Galluzzi, Lorenzo, Adjemian, Sandy, Kepp, Oliver, Niso Santano, Mireia, Shen, Shensi, Mariño, Guillermo, Criollo, Alfredo, Boilève, Alice, Job, Bastien, Ladoire, Sylvain, Ghiringhelli, Françoi, Sistigu, Antonella, Yamazaki, Takahiro, Rello Varona, Santiago, Locher, Clara, Poirier Colame, Vichnou, Talbot, Monique, Valent, Alexander, Ciccosanti, Fabiola, Fimia, Gian Maria, Piacentini, Mauro, Fueyo, Antonio, Messina, Nicole L, Li, Ming, Chan, Christopher J, Sigl, Verena, Pourcher, Guillaume, Ruckenstuhl, Christoph, Carmona Gutierrez, Didac, Lazar, Vladimir, Penninger, Josef M, Madeo, Frank, López Otín, Carlo, Smyth, Mark J, Zitvogel, Laurence, Castedo, Maria, Kroemer, Guido |
| Rok vydání: | 2012 |
| Předmět: |
Settore BIO/06
Eukaryotic Initiation Factor-2 medicine.disease_cause Cell Line Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Neoplasms medicine Animals Humans Epigenetics Phosphorylation Endoplasmic Reticulum Stre Immunologic Surveillance Inbred BALB C 030304 developmental biology Mice Inbred BALB C 0303 health sciences Tumor Ploidies Multidisciplinary biology Animal Endoplasmic reticulum Cancer DNA Neoplasm DNA Endoplasmic Reticulum Stress medicine.disease 3. Good health Immunosurveillance Common Variable Immunodeficiency Cell culture 030220 oncology & carcinogenesis Cancer cell Immunology biology.protein Cancer research Neoplasm Calreticulin Carcinogenesis Immunocompetence Human |
| Zdroj: | Science. 337:1678-1684 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Keeping Cancer Cells At Bay Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear. Senovilla et al. (p. 1678 ; see the Perspective by Zanetti and Mahadevan ) found that tetraploidization of cancer cells can cause them to become immunogenic and thus aid in their clearance from the body by the immune system. Cells with excess chromosomes put stress on the endoplasmic reticulum, which leads to movement of the protein calreticulin to the cell surface. Calreticulin exposure in turn caused recognition of cancer cells in mice by the host immune system. Thus, the immune system appears to serve a protective role in eliminating hyperploid cells that must be overcome to allow unrestricted growth of cancer cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|