Recipient/donor HLA and CMV matching in recipients of T-cell-depleted unrelated donor haematopoietic cell transplants
| Autor: | Nigel H. Russell, J. A. Madrigal, Kirsty Thomson, Michael Potter, Bronwen E. Shaw, Antonio Pagliuca, Chloe Anthias, A Clark, John Perry, Keiren Kirkland, WP Bultitude, Richard Szydlo, David I. Marks, Sge Marsh, Neema P. Mayor, Stephen Mackinnon |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cytomegalovirus Human leukocyte antigen Gastroenterology Lymphocyte Depletion 03 medical and health sciences Young Adult 0302 clinical medicine HLA Antigens Risk Factors Internal medicine medicine Humans Serologic Tests Child Survival analysis Aged Transplantation Donor selection business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease HLA Mismatch Survival Analysis Confidence interval Histocompatibility Graft-versus-host disease 030220 oncology & carcinogenesis Child Preschool Hematologic Neoplasms Immunology Female business Unrelated Donors 030215 immunology |
| Zdroj: | Bone marrow transplantation. 52(5) |
| ISSN: | 1476-5365 |
| Popis: | Improving haematopoietic cell transplantation outcomes by selection of an HLA-matched unrelated donor is best practice; however, donor selection by secondary characteristics is controversial. We studied 1271 recipients with haematological malignancies who underwent T-cell-depleted allografts and had complete data on HLA-matching status for six loci (HLA-A, -B, -C, -DRB1, -DQB1, -DPB1) and clinical outcome data. Five-year overall survival was 40.6%. HLA mismatching (at HLA-A, -B, -C, -DRB1, -DQB1) relative risk (RR) 1.22, 95% confidence interval (CI) 1.2-1.5, P=0.033 for 1 mismatch and RR 1.46, 95% CI 1.1-1.9, P=0.009 for >1 mismatch) and CMV mismatching (RR 1.37, 95% CI 1.2-1.6, P |
| Databáze: | OpenAIRE |
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