Analysis of cranial adult pilocytic astrocytomas over a 10 year period
| Autor: | Alex Leggate, Erjon Agushi, Konstantina Karabatsou, Pietro Ivo D'Urso, Federico Roncaroli, David Coope, Eva Bourama |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pilocytic astrocytoma business.industry Pulmonary artery stenosis medicine.medical_treatment Objective (goal) Period (gene) Pilocytic Astrocytomas medicine.disease Gastroenterology Chemotherapy regimen Radiation therapy Abstracts Oncology Internal medicine medicine Neurology (clinical) Progression-free survival business |
| Popis: | OBJECTIVES: Review of clinical features and outcomes in patients with adult pilocytic astrocytoma (PA). DESIGN: Retrospective study of all adult PAs treated in our centre using clinical & pathological data. SUBJECTS: 55 cases of pilocytic astrocytomas (>16 y old). METHODS: All adult patients with histologically proved cranial PA operated between 2007 and 2017. Analysis was performed using STATA 11.0 (Stata Corp LP). RESULTS: 55 patients with PA were reviewed: 26 M/29 F. 9 had NF 1. PA was first diagnosed in childhood in 12 patients. Patients diagnosed before 18 years experienced a greater number of recurrences (p=0.023). Mean follow up was 8.4 years. The most frequent tumour locations were the cerebral lobes (41.8%) and cerebellum (32.7%). PA WHO grade I was confirmed histologically in 89.9% of cases. 22 patients underwent radiotherapy, of which 8 (36, 6%) had also chemotherapy. Tumour recurrence occurred in 19 patients (34.5%). WHO grade was an independent predictor of tumour recurrence (p=0.02). Of the 19 recurrences, 5 (26.4%) had a total/near total resection (p=0.014). Patients with incomplete resections had higher rates of post-surgical radiotherapy (p=0.018). Progression-free survival was longer in patients with WHO grade I tumours that had total resection. Radiotherapy did not improve progression-free survival rates (p=0.54). CONCLUSIONS: Recurrence in PAs seems to depend on the age of first diagnosis. WHO grade and extension of resection were independent predictors of progression-free survival, although resection was largely dependent on tumour location. Adjuvant radiotherapy in incomplete resections did not impede disease progression although mean times to recurrence were longer in the radiotherapy group. |
| Databáze: | OpenAIRE |
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