Studies on the Role of Adhesive Proteins in Maintaining Pregnancy
| Autor: | Takao Kobayashi, Yoshichika Okada, Y Inamoto, Toshihiko Terao, Toshihiko Asahina, Miwa Yamashita, Mariko Itoh |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Placenta Endocrinology Diabetes and Metabolism Early pregnancy factor Fibrinogen Endometrium chemistry.chemical_compound Fetus Endocrinology Pregnancy Internal medicine medicine Humans Macrophage Tissue Distribution Factor XIII biology Factor X Afibrinogenemia medicine.disease Factor XIII Deficiency Immunohistochemistry Adhesive proteins Abortion Spontaneous Fibronectin Pregnancy Trimester First chemistry Pediatrics Perinatology and Child Health biology.protein Female medicine.drug |
| Zdroj: | Hormone Research in Paediatrics. 50:37-45 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000053122 |
| Popis: | It is well known that maternal fibrinogen (Fg) and factor X III are essential for maintaining early pregnancy. We studied their role by analysis of clinical reports and immunohistochemical investigation. Methods: (1) We analyzed the pregnancy cases of congenital afibrinogenemia and congenital factor X III deficiency. (2) Immunohistochemical staining of Fg, subunit A of factor X III (X IIIA) and fibronectin (Fn) were performed in the human implantation site, placenta, and endometrial cells cultured in serum-free medium. Results: (1) Afibrinogenemia needed to be administrated Fg from 4 weeks’ gestation (4 wG), and factor X III deficiency needed factor X III concentrate from 5 wG, in order to prevent abortion. (2) Implantation tissues: Fg, cellular X IIIA and Fn were present at the decidual stroma around invasive cytotrophoblasts at 5 wG. X IIIA-positive cells coincided with LN-5-positive macrophages. Placenta: Fg, cellular X IIIA and Fn were present in the decidual layer. Endometrial culture cells: Fn was secreted by spindle-like shaped cells. X IIIA was secreted by round-shaped cells. Conclusion: Maternal Fg and factor X III are essential just after 4∼5 wG, and in that period they and Fn are present abundantly in decidual stroma around invasive cytotrophoblasts. It is concluded that when cytotrophoblasts invade endometrium maternal Fg, factor X III and Fn are concerned with cytotrophoblasts’ anchoring as adhesive proteins. |
| Databáze: | OpenAIRE |
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