High dose chemotherapy with stem-cell transplantation in a metastatic medulloblastoma in an adult: a case report and review of the literature
| Autor: | Laurent Mignot, Bernard Visot, Sylvie Giacchetti, Michel Marty, Paul Cottu, Jean Marc Extra, Marc Espié, Bernard Epardeau |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Vinblastine Metastasis Bleomycin Therapeutic approach Autologous stem-cell transplantation Antineoplastic Combined Chemotherapy Protocols medicine Humans Mechlorethamine Cerebellar Neoplasms Bone Marrow Transplantation Medulloblastoma Chemotherapy business.industry medicine.disease Combined Modality Therapy Surgery Dacarbazine Transplantation Radiation therapy Neurology Oncology Doxorubicin Vincristine Procarbazine Prednisone Neurology (clinical) Radiology Stem cell business Stem Cell Transplantation |
| Zdroj: | Journal of Neuro-Oncology. 18:19-23 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/bf01324599 |
| Popis: | Medulloblastoma is a rare tumor in adult. High doses of megavoltage irradiation of the posterior fossa have been resulted in a better survival (48 to 78% at 5 years) of the patient. It is sensitive to a wide variety of chemotherapy drugs, but adjuvant chemotherapy has not been proved effective in adults although data are limited. We report the case of a cerebellar medulloblastoma with bony and medullar metastases. High-dose chemotherapy with peripheral stem-cell transplantation was performed while the patient was in remission following conventional chemotherapy. Complete remission lasted for 8 months. This therapeutic approach of metastatic medulloblastoma might be of value as this tumor is chemosensitive and not cured by conventional treatment. Internal radiotherapy by Samarium-153 was also carried out and proved to be an effective palliative treatment of pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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