Cerebrospinal fluid levels of GFAP and pNF-H are elevated in patients with chronic spinal cord injury and neurological deterioration
| Autor: | Parmenion P. Tsitsopoulos, Niklas Marklund, Konstantin Salci, Gerry Shaw, Ulrika Holmström, Stefania Mondello, Anders Holtz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Neurologi Biomarkers Cerebrospinal fluid Glial fibrillary acidic protein (GFAP) Neurofilament Post-traumatic myelopathy Spinal cord injury Syringomyelia Tethering of the spinal cord (TSC) Ubiquitin C-terminal hydrolase L1 (UCH-L1) Female Glial Fibrillary Acidic Protein Humans Middle Aged Neurofilament Proteins Spinal Cord Injuries Glial scar 03 medical and health sciences 0302 clinical medicine Lumbar medicine Original Article - Spine - Other Glial fibrillary acidic protein biology business.industry Neurosciences medicine.disease Spinal cord 030104 developmental biology medicine.anatomical_structure Neurology biology.protein Surgery Neurology (clinical) business Meningitis Neurovetenskaper 030217 neurology & neurosurgery |
| Zdroj: | Acta Neurochirurgica |
| ISSN: | 0942-0940 0001-6268 |
| DOI: | 10.1007/s00701-020-04422-6 |
| Popis: | Background Years after a traumatic spinal cord injury (SCI), a subset of patients may develop progressive clinical deterioration due to intradural scar formation and spinal cord tethering, with or without an associated syringomyelia. Meningitis, intradural hemorrhages, or intradural tumor surgery may also trigger glial scar formation and spinal cord tethering, leading to neurological worsening. Surgery is the treatment of choice in these chronic SCI patients. Objective We hypothesized that cerebrospinal fluid (CSF) and plasma biomarkers could track ongoing neuronal loss and scar formation in patients with spinal cord tethering and are associated with clinical symptoms. Methods We prospectively enrolled 12 patients with spinal cord tethering and measured glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase L1 (UCH-L1), and phosphorylated Neurofilament-heavy (pNF-H) in CSF and blood. Seven patients with benign lumbar intradural tumors and 7 patients with cervical radiculopathy without spinal cord involvement served as controls. Results All evaluated biomarker levels were markedly higher in CSF than in plasma, without any correlation between the two compartments. When compared with radiculopathy controls, CSF GFAP and pNF-H levels were higher in patients with spinal cord tethering (p ≤ 0.05). In contrast, CSF UCH-L1 levels were not altered in chronic SCI patients when compared with either control groups. Conclusions The present findings suggest that in patients with spinal cord tethering, CSF GFAP and pNF-H levels might reflect ongoing scar formation and neuronal injury potentially responsible for progressive neurological deterioration. |
| Databáze: | OpenAIRE |
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