N-Terminal amino acid sequences of the .alpha. and .beta. chains of HLA-DR1 and HLA-DR2 antigens
| Autor: | William J. Dreyer, Rodney M. Hewick, Michael W. Hunkapiller, Leroy Hood, Ralph A. Reisfeld, Leslie E. Walker |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
chemistry.chemical_classification
Chromatography Gas Macromolecular Substances HLA-DR1 HLA-DR1 Antigen Histocompatibility Antigens Class II Alpha (ethology) chemical and pharmacologic phenomena HLA-DR Antigens Biochemistry Peptide Fragments Amino acid Molecular Weight Antigen chemistry Polymorphism (computer science) Humans Electrophoresis Polyacrylamide Gel Amino Acid Sequence Beta (finance) Peptide sequence |
| Zdroj: | Biochemistry. 22:185-188 |
| ISSN: | 1520-4995 0006-2960 |
| Popis: | The N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens were obtained with subnanomole quantities of material by using a gas-liquid solid-phase sequencer. A comparison of the N-terminal amino acid sequences of HLA-DR1 and HLA-DR2 alpha chains revealed no differences. However, in the first 35 N-terminal residues of the beta chains from HLA-DR1 and HLA-DR2 antigens, two regions of variability are readily apparent, each comprising about six amino acids. Conceivably one or both of these variability regions may be responsible for the serologically defined polymorphism of HLA-DR alloantigens. |
| Databáze: | OpenAIRE |
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