Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems
| Autor: | Sara Marques, Bruno Sarmento, Teófilo Vasconcelos |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Chemistry Pharmaceutical Biological Availability Pharmaceutical Science Self emulsifying 02 engineering and technology 030226 pharmacology & pharmacy Stability (probability) Excipients 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Continuous evaluation Drug Stability Particle Size Process engineering Drug Carriers Chromatography business.industry General Medicine 021001 nanoscience & nanotechnology Solubility Emulsifying Agents Scientific method Emulsion Drug delivery Nanoparticles Emulsions Physical stability 0210 nano-technology business Drug carrier Biotechnology |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 123:1-8 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/j.ejpb.2017.11.003 |
| Popis: | Self-emulsifying drug delivery systems (SEDDS) are one of the most promising technologies in the drug delivery field, particularly for addressing solubility and bioavailability issues of drugs. The development of these drug carriers excessively relies in visual observations and indirect determinations. The present manuscript intended to describe a method able to measure the emulsification of SEDDS, both micro and nano-emulsions, able to measure the droplet size and to evaluate the physical stability of these formulations. Additionally, a new process to evaluate the physical stability of SEDDS after emulsification was also proposed, based on a cycle of mechanical stress followed by a resting period. The use of a multiparameter continuous evaluation during the emulsification process and stability was of upmost value to understand SEDDS emulsification process. Based on this method, SEDDS were classified as fast and slow emulsifiers. Moreover, emulsification process and stabilization of emulsion was subject of several considerations regarding the composition of SEDDS as major factor that affects stability to physical stress and the use of multicomponent with different properties to develop a stable and robust SEDDS formulation. Drug loading level is herein suggested to impact droplets size of SEDDS after dispersion and SEDDS stability to stress conditions. The proposed protocol allows an online measurement of SEDDS droplet size during emulsification and a rationale selection of excipients based on its emulsification and stabilization performance. |
| Databáze: | OpenAIRE |
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