Dutch Prospective Observational Study on Prehospital Treatment of Severe Traumatic Brain Injury: The BRAIN-PROTECT Study Protocol
| Autor: | Bossers, SM, Boer, C, Greuters, S, Bloemers, FW, den Hartog, Dennis, Van Lieshout, Esther M.M., Hoogerwerf, N, Innemee, G, van der Naalt, J, Absalom, AR, Peerdeman, SM, Visser, M, Loer, S, Schober, P, Boer, D, Goslings, JC, van Helden, SH, Hesselink, DA, van Aken, G, Beishuizen, A, Egberink, RE, ter Bogt, N, de Jongh, MAC, Lansink, K, Roks, G, Joosse, P, Ponsen, KJ, van Spengler, LL, Aspers, S, de Leeuw, MA, Schwarte, LA, Toor, A, Houmes, RJM, Ditshuizen, Jan, van Voorden, Tea, Edwards, MJR, Dercksen, B, Spanjersberg, R, Venema, L, Weelink, E, Reininga, HF |
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| Přispěvatelé: | Surgery, Emergency Medicine, Anesthesiology, IOO, ACS - Diabetes & metabolism, ACS - Microcirculation, APH - Quality of Care, Amsterdam Movement Sciences - Restoration and Development, Other Research, Neurosurgery, AII - Inflammatory diseases, APH - Methodology, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Molecular Neuroscience and Ageing Research (MOLAR) |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Emergency Medical Services Adolescent Traumatic brain injury Psychological intervention 030204 cardiovascular system & hematology Emergency Nursing Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences Young Adult 0302 clinical medicine Clinical Protocols Trauma Centers Epidemiology Brain Injuries Traumatic Emergency medical services Medicine Humans Glasgow Coma Scale Prospective Studies Registries Child Aged Netherlands Aged 80 and over business.industry Mortality rate Head injury Infant 030208 emergency & critical care medicine Middle Aged medicine.disease Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] Child Preschool Emergency medicine Emergency Medicine Observational study Female business |
| Zdroj: | Prehospital Emergency Care, 23(6), 820-827. Taylor & Francis Ltd PREHOSPITAL EMERGENCY CARE, 23(6), 820-827. Taylor and Francis Ltd. Bossers, S M, Boer, C, Greuters, S, Bloemers, F W, Den Hartog, D, Van Lieshout, E M M, Hoogerwerf, N, Innemee, G, van der Naalt, J, Absalom, A R, Peerdeman, S M, de Visser, M, Loer, S & Schober, P 2019, ' Dutch Prospective Observational Study on Prehospital Treatment of Severe Traumatic Brain Injury : The BRAIN-PROTECT Study Protocol ', PREHOSPITAL EMERGENCY CARE, vol. 23, no. 6, pp. 820-827 . https://doi.org/10.1080/10903127.2019.1587126 Prehospital emergency care, 23, 820-827 Prehospital emergency care, 23, 6, pp. 820-827 Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, 23(6), 820-827. Taylor & Francis Group |
| ISSN: | 1090-3127 |
| DOI: | 10.1080/10903127.2019.1587126 |
| Popis: | Contains fulltext : 215205.pdf (Publisher’s version ) (Open Access) Background: Severe traumatic brain injury (TBI) is associated with a high mortality rate and those that survive commonly have permanent disability. While there is a broad consensus that appropriate prehospital treatment is crucial for a favorable neurological outcome, evidence to support currently applied treatment strategies is scarce. In particular, the relationship between prehospital treatments and patient outcomes is unclear. The BRAIN-PROTECT study therefore aims to identify prehospital treatment strategies associated with beneficial or detrimental outcomes. Here, we present the study protocol. Study Protocol: BRAIN-PROTECT is the acronym for BRAin INjury: Prehospital Registry of Outcome, Treatments and Epidemiology of Cerebral Trauma. It is a prospective observational study on the prehospital treatment of patients with suspected severe TBI in the Netherlands. Prehospital epidemiology, interventions, medication strategies, and nonmedical factors that may affect outcome are studied. Multivariable regression based modeling will be used to identify confounder-adjusted relationships between these factors and patient outcomes, including mortality at 30 days (primary outcome) or mortality and functional neurological outcome at 1 year (secondary outcomes). Patients in whom severe TBI is suspected during prehospital treatment (Glasgow Coma Scale score |
| Databáze: | OpenAIRE |
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