Calculation of Transmembrane Current From Extracellular Potential Recordings: A Model Study
| Autor: | Francis X. Witkowski, L. Joshua Leon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Decremental conduction
Membrane Potentials Electrocardiography Extracellular potential Dogs Nuclear magnetic resonance Heart Conduction System Physiology (medical) Animals Waveform Medicine Computer Simulation Sinus rhythm Fourier Analysis business.industry Model study Heart Thermal conduction Electric Stimulation Electrophysiology Heart Block Ventricular Fibrillation Current (fluid) Extracellular Space Cardiology and Cardiovascular Medicine business Transmembrane current Algorithms |
| Zdroj: | Journal of Cardiovascular Electrophysiology. 6:379-390 |
| ISSN: | 1540-8167 1045-3873 |
| DOI: | 10.1111/j.1540-8167.1995.tb00411.x |
| Popis: | Transmembrane Current Estimation. Introduction: A mathematical/computer model of cardiac tissue was used to study the estimation of transmembrane current (EIm) from extracellular potential recordings. Methods and Results: The simulated EIm of transmembrane current was compared with the simulated transmembrane current (Im), and both simulated values were compared with experimentally derived EIm obtained during sinus rhythm and ventricular fibrillation in dogs. We found that although EIm measurements slightly overestimate the duration of the Im waveform, they provide a reasonable approximation of Im during normal conduction and during decremental conduction and conduction block. Conclusions: There is a very clear linear correlation between the time spent at or below 25% of the peak inward transmembrane current (Im25), its corresponding estimate (EI25), the peak inward Im and EIm and the peak ionic current, providing some evidence that EIm25 may be a suitable in vivo measure of peak ionic current. |
| Databáze: | OpenAIRE |
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