Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility
| Autor: | Emma Pomeroy, Veena Mushrif-Tripathy, Tim J Cole, Jay T. Stock, Jonathan C. K. Wells |
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| Přispěvatelé: | Pomeroy, Emma [0000-0001-6251-2165], Mushrif-Tripathy, Veena [0000-0002-4749-1316], Cole, Tim J [0000-0001-5711-8200], Apollo - University of Cambridge Repository, Cole, Tim J. [0000-0001-5711-8200] |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male South asia Asia Biological anthropology Climate Climatic adaptation lcsh:Medicine Type 2 diabetes History 21st Century White People Disease rates 03 medical and health sciences 0302 clinical medicine Asian People Thinness 692/699/2743/137/773 medicine Humans Genetic Predisposition to Disease Obesity lcsh:Science History Ancient Skeleton Adiposity 2. Zero hunger Multidisciplinary Anthropometry Fossils lcsh:R article Lean tissue 631/181/19/2471 medicine.disease Adaptation Physiological Body Height Diet 030104 developmental biology Geography Diabetes Mellitus Type 2 Lean body mass lcsh:Q Female 030217 neurology & neurosurgery Demography |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| Popis: | Living South Asians have low lean tissue mass relative to height, which contributes to their elevated type 2 diabetes susceptibility, particularly when accompanied by obesity. While ongoing lifestyle transitions account for rising obesity, the origins of low lean mass remain unclear. We analysed proxies for lean mass and stature among South Asian skeletons spanning the last 11,000 years (n = 197) to investigate the origins of South Asian low lean mass. Compared with a worldwide sample (n = 2,003), South Asian skeletons indicate low lean mass. Stature-adjusted lean mass increased significantly over time in South Asia, but to a very minor extent (0.04 z-score units per 1,000 years, adjusted R2 = 0.01). In contrast stature decreased sharply when agriculture was adopted. Our results indicate that low lean mass has characterised South Asians since at least the early Holocene and may represent long-term climatic adaptation or neutral variation. This phenotype is therefore unlikely to change extensively in the short term, so other strategies to address increasing non-communicable disease rates must be pursued. |
| Databáze: | OpenAIRE |
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