Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy
| Autor: | Shi-Biao Wu, Kathleen Whalen, Edward J. Kennelly, Kurt A. Reynertson, Robert F. Foronjy, Jeanine M. D´Armiento, Chunhui Ma, Abdoulaye J. Dabo, Keyvan Dastmalchi, Gema Flores |
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| Rok vydání: | 2012 |
| Předmět: |
Ellagic acid
Myrtaceae Clinical Biochemistry Myrciaria vexator Pharmaceutical Science Hyperoside Fractionation Biochemistry Depsides Mass Spectrometry Article Protocatechuic acid Anthocyanins Pulmonary Disease Chronic Obstructive chemistry.chemical_compound Phenols Petunidin Drug Discovery Botany Humans COPD Food science Molecular Biology MMP-1 inhibition Cells Cultured Chromatography High Pressure Liquid biology Organic Chemistry Epithelial Cells Free Radical Scavengers biology.organism_classification Malvidin chemistry Fruit Molecular Medicine Matrix Metalloproteinase 1 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16). |
| Databáze: | OpenAIRE |
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