Toward Primary Prevention of Asthma. Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma
| Autor: | Marc B. Hershenson, Martin L. Moore, Amy S. Feldman, Tina V. Hartert, Yuan He |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pulmonary Perspective Rhinovirus viruses Respiratory Syncytial Virus Infections Disease Antibodies Monoclonal Humanized Critical Care and Intensive Care Medicine medicine.disease_cause Antiviral Agents Severity of Illness Index Virus Epigenesis Genetic Risk Factors Primary prevention Correspondence medicine Humans Genetic Predisposition to Disease Respiratory system Intensive care medicine Respiratory Tract Infections Palivizumab Asthma Childhood asthma Respiratory tract infections business.industry Microbiota Infant Environmental Exposure medicine.disease Diet Respiratory Syncytial Viruses Primary Prevention Child Preschool Tobacco Smoke Pollution business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 191:34-44 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.201405-0901pp |
| Popis: | A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts. |
| Databáze: | OpenAIRE |
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