Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats
| Autor: | Nathan Lamborn, Vesna Jevtovic-Todorovic, Sonja Lj. Joksimovic, Slobodan M. Todorovic |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gene isoform Alpha-Lipoic Acid Surgical Wound Biophysics Biochemistry Spontaneous pain 03 medical and health sciences 0302 clinical medicine Medicine Animals Postsurgical pain Acute pain Pain Postoperative Skin incision Thioctic Acid business.industry T-type calcium channel acute pain Rats 030104 developmental biology Hyperalgesia Anesthesia Alpha lipoic acid novel analgesics business 030217 neurology & neurosurgery Research Article Research Paper |
| Zdroj: | Channels article-version (VoR) Version of Record |
| ISSN: | 1933-6969 |
| Popis: | Our previous studies have implicated CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of postsurgical pain. We have also previously established that different T-channel antagonists can alleviate in vivo postsurgical pain. Here we investigated the analgesic potential of another T-channel blocker and endogenous antioxidant molecule, α-lipoic acid (ALA), in a postsurgical pain model in rats. Our in vivo results suggest that single and repetitive intraperitoneal injections of ALA after surgery or preemptively, significantly reduced evoked mechanical hyperalgesia following surgical paw incision. Furthermore, repeated preemptive systemic injections of ALA effectively alleviated spontaneous postsurgical pain as determined by dynamic weight-bearing testing. We expect that our preclinical study may lead to further investigation of analgesic properties and mechanisms of analgesic action of ALA in patients undergoing surgery. |
| Databáze: | OpenAIRE |
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