IL-3 promotes the development of experimental autoimmune encephalitis
| Autor: | Manuel Rodriguez Gomez, Fabian Hermann, Nicole Goebel, Yvonne Talke, Gabriela Schiechl, Christine Riedhammer, Matthias Mack, Simone Kutzi, Sonja Hellerbrand, Kerstin Renner, Robert Weissert, Dagmar Halbritter, Hilke Brühl |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult CD4-Positive T-Lymphocytes Male Chemokine Adoptive cell transfer Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Encephalomyelitis Myelin oligodendrocyte glycoprotein 03 medical and health sciences Mice 0302 clinical medicine immune system diseases medicine Animals Humans Interleukin 3 Autoimmune encephalitis biology business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis Antibodies Monoclonal General Medicine medicine.disease Adoptive Transfer nervous system diseases Mice Inbred C57BL 030104 developmental biology Immunology biology.protein Female Interleukin-3 Myelin-Oligodendrocyte Glycoprotein Chemokines business Cell Adhesion Molecules 030217 neurology & neurosurgery Research Article |
| Popis: | Little is known about the role of IL-3 in multiple sclerosis (MS) in humans and in experimental autoimmune encephalomyelitis (EAE). Using myelin oligodendrocyte glycoprotein (MOG) peptide-induced EAE, we show that CD4+ T cells are the main source of IL-3 and that cerebral IL-3 expression correlates with the influx of T cells into the brain. Blockade of IL-3 with monoclonal antibodies, analysis of IL-3 deficient mice, and adoptive transfer of leukocytes demonstrate that IL-3 plays an important role for development of clinical symptoms of EAE, for migration of leukocytes into the brain, and for cerebral expression of adhesion molecules and chemokines. In contrast, injection of recombinant IL-3 exacerbates EAE symptoms and cerebral inflammation. In patients with relapsing-remitting MS (RRMS), IL-3 expression by T cells is markedly upregulated during episodes of relapse. Our data indicate that IL-3 plays an important role in EAE and may represent a new target for treatment of MS. |
| Databáze: | OpenAIRE |
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