Granulomas and cholestatic-hepatocellular injury associated with phenylbutazone
| Autor: | J. K. Dhar, Kamal G. Ishak, John P. Kirchner |
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| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Physiology Gastroenterology Oxyphenbutazone Hepatic function Internal medicine medicine Phenylbutazone Humans Eosinophilia Aged Cholestasis Diazepam Granuloma medicine.diagnostic_test business.industry Liver Diseases Chlordiazepoxide General Medicine Middle Aged Hepatology Liver Liver biopsy Macular Rash Peripheral Blood Eosinophilia Hepatocellular injury Chemical and Drug Induced Liver Injury medicine.symptom business medicine.drug |
| Zdroj: | The American Journal of Digestive Diseases. 22:611-617 |
| ISSN: | 1573-2568 0002-9211 |
| DOI: | 10.1007/bf01073079 |
| Popis: | A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy. Both patients were jaundiced, one had a macular rash, and both had peripheral blood eosinophilia. Symptoms and signs subsided, and abnormal findings from tests of hepatic function rapidly returned to normal following withdrawal of the drug. Sections of liver biopsy specimens 6 months later showed no granulomas or other pathologic changes. Previously reported cases are reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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