LncARSR sponges miR-129-5p to promote proliferation and metastasis of bladder cancer cells through increasing SOX4 expression
| Autor: | Chunxian Liao, Zhaolin Long, Fuming Qi, Xinji Zhang, Shihao Wu, Jianli Cheng, Tao Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Epithelial-Mesenchymal Transition
Biology Real-Time Polymerase Chain Reaction Applied Microbiology and Biotechnology SOXC Transcription Factors Metastasis Pathogenesis 03 medical and health sciences SOX4 Cell Line Tumor medicine Humans Neoplasm Metastasis Molecular Biology Transcription factor Ecology Evolution Behavior and Systematics Cell Proliferation 030304 developmental biology Wound Healing 0303 health sciences Bladder cancer Competing endogenous RNA Sunitinib Cancer ceRNA Cell Biology medicine.disease Gene Expression Regulation Neoplastic MicroRNAs lncARSR miR-129-5p Urinary Bladder Neoplasms Disease Progression Cancer research RNA Long Noncoding Research Paper Developmental Biology medicine.drug |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Emerging evidences have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers, playing important roles in the development of cancer. LncRNA Activated in RCC with Sunitinib Resistance (lncARSR) is a novel lncRNA that functions as a potential biomarker and is involved in the progression of cancers. However, the clinical significance and molecular mechanism of lncARSR in bladder cancer (Bca) remains unknow. In this study, we discovered that lncARSR was significantly up-regulated in bladder cancer. In addition, increased expression of lncARSR was positively correlated with higher histological grade and larger tumor size. Further experiments demonstrated that suppression of lncARSR attenuated the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process of Bca cells. Mechanistically, lncARSR was mainly located in the cytoplasm and acted as a miRNA sponge to positively modulate the expression of Sex-determining region Y-related high-mobility-group box transcription factor 4 (SOX4) via sponging miR-129-5p and subsequently promoted the proliferation and metastasis of Bca cells, thus playing an oncogenic role in Bca pathogenesis. In conclusion, our study indicated that lncARSR plays a critical regulatory role in Bca cells and lncARSR may serve as a potential diagnostic biomarker and therapeutic target for bladder cancer. |
| Databáze: | OpenAIRE |
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