Effects of Energy-Matched Pulsed and Continuous Ultrasound on Tumor Growth in Mice
| Autor: | Michael Eckhaus, Julie A Guthrie, Lola Sicard-Rosenbaum, Jerome V Danoff |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Ultrasonic Therapy medicine.medical_treatment Pilot Projects Physical Therapy Sports Therapy and Rehabilitation Mice Random Allocation Sonication chemistry.chemical_compound Rhabdomyosarcoma medicine Animals Tumor growth Contraindication Analysis of Variance Therapeutic ultrasound business.industry Ultrasound medicine.disease Surgery Mice Inbred C57BL chemistry Evaluation Studies as Topic Methylcholanthrene Female Analysis of variance Nuclear medicine business After treatment |
| Zdroj: | Physical Therapy. 78:271-277 |
| ISSN: | 1538-6724 0031-9023 |
| DOI: | 10.1093/ptj/78.3.271 |
| Popis: | Background and Purpose. A diagnosis of cancer is a contraindication for the use of therapeutic ultrasound (US). Continuous US applied to murine tumors has resulted in larger and heavier tumors compared with controls. We compared tumor growth using low-power continuous US and energy-matched pulsed US. Subjects. Female C57BL/6 mice (N=174) were used. Methods. Animals received subcutaneous injections of methylcholanthrene tumor cells. The mice were randomly divided into three groups: 60 mice that received low-power continuous US for 5 minutes at 0.75 W/cm2 (LC US group), 63 mice that received pulsed US for 12.5 minutes at 1.5 W/cm2 (pulsed US group), and 51 mice that served as a control group. The LC and pulsed US groups received equal US energy. Both experimental groups received 10 treatments of 3-MHz US, which was applied directly over the tumor. The control group received identical handling but no US. After treatment, the tumors were excised, weighed, and measured. A one-way analysis of variance, followed by Newman-Keuls post hoc testing, was used to analyze the data. Results. Mean tumor weights (in grams) and volumes (in cubic millimeters) were 0.563 g and 564 mm3 for the LC US group, 0.560 g and 525 mm3 for the pulsed US group, and 0.516 g and 406 mm3 for the control group. Conclusion and Discussion. Reducing total US energy will result in less growth of murine tumors. When infusing equal energy, continuous and pulsed US will produce similar effects on tumor growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|