810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice
| Autor: | Fannie Darlot, John Mitrofanis, Napoleon Torres, Thomas Costecalde, Claude Chabrol, Nabil El Massri, Cécile Moro, Alim-Louis Benabid, Florian Reinhart, Daniel M. Johnstone, Jonathan Stone |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Tyrosine 3-Monooxygenase Infrared Rays Substantia nigra Cell Count Pharmacology Motor Activity Locomotor activity Neuroprotection chemistry.chemical_compound Mice Parkinsonian Disorders Dopaminergic Cell Animals Low-Level Light Therapy Pars Compacta Tyrosine hydroxylase immunohistochemistry Mice Inbred BALB C Near infrared light Tyrosine hydroxylase Chemistry General Neuroscience MPTP Dopaminergic Neurons General Medicine nervous system diseases Neuroscience |
| Zdroj: | Neuroscience research. 92 |
| ISSN: | 1872-8111 |
| Popis: | We explored whether 810 nm near-infrared light (NIr) offered neuroprotection and/or improvement in locomotor activity in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. Mice received MPTP and 810 nm NIr treatments, or not, and were tested for locomotive activity in an open-field test. Thereafter, brains were aldehyde-fixed and processed for tyrosine hydroxylase immunohistochemistry. Our results showed that MPTP-treated mice that were irradiated with 810 nm NIr had both greater locomotor activity (∼40%) and number of dopaminergic cells (∼20%) than those that were not. In summary, 810 nm (as with 670 nm) NIr offered neuroprotection and improved locomotor activity in MPTP-treated mice. |
| Databáze: | OpenAIRE |
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