Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events
| Autor: | L. Korányi, Osborne F. X. Almeida, Vladimir K. Patchev, A. Montkowski, D. Rouskova, Florian Holsboer |
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| Rok vydání: | 1997 |
| Předmět: |
Agonist
Male medicine.medical_specialty Neuroactive steroid Transcription Genetic medicine.drug_class Corticotropin-Releasing Hormone Hypothalamus Anxiety Hippocampus GABA Antagonists chemistry.chemical_compound Corticotropin-releasing hormone Glucocorticoid receptor Receptors Glucocorticoid Receptors GABA Pregnancy Stress Physiological Internal medicine medicine Animals Humans RNA Messenger Rats Wistar Desoxycorticosterone Glucocorticoids In Situ Hybridization Behavior Animal business.industry Infant Newborn General Medicine Neurosecretory Systems Tetrahydrodeoxycorticosterone Rats Endocrinology chemistry Anti-Anxiety Agents Adrenal Cortex Female business Glucocorticoid Hormone medicine.drug Research Article |
| Zdroj: | ResearcherID CIÊNCIAVITAE |
| ISSN: | 0021-9738 |
| Popis: | Stressful experience during early brain development has been shown to produce profound alterations in several mechanisms of adaptation, while several signs of behavioral and neuroendocrine impairment resulting from neonatal exposure to stress resemble symptoms of dysregulation associated with major depression. This study demonstrates that when applied concomitantly with the stressful challenge, the steroid GABA(A) receptor agonist 3,21-dihydropregnan-20-one (tetrahydrodeoxycorticosterone, THDOC) can attenuate the behavioral and neuroendocrine consequences of repeated maternal separation during early life, e.g., increased anxiety, an exaggerated adrenocortical secretory response to stress, impaired responsiveness to glucocorticoid feedback, and altered transcription of the genes encoding corticotropin-releasing hormone (CRH) in the hypothalamus and glucocorticoid receptors in the hippocampus. These data indicate that neuroactive steroid derivatives with GABA-agonistic properties may exert persisting stress-protective effects in the developing brain, and may form the basis for therapeutic agents which have the potential to prevent mental disorders resulting from adverse experience during neonatal life. |
| Databáze: | OpenAIRE |
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