Natural Product-Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as a New Antifungal Template

Autor:	Melissa R. Jacob, K. Suresh Babu, Ameeta K. Agarwal, Xing-Cong Li, Shabana I. Khan, Alice M. Clark
Rok vydání:	2011
Předmět:	Antifungal Scaffold Natural product Chemistry medicine.drug_class Organic Chemistry Nanotechnology Biochemistry Combinatorial chemistry In vitro chemistry.chemical_compound Drug Discovery medicine Side chain Moiety Pharmacophore
Zdroj:	ACS Medicinal Chemistry Letters. 2:391-395
ISSN:	1948-5875
DOI:	10.1021/ml200020h
Popis:	Synthetic analogues of the marine-derived class of natural products phloeodictines have been prepared and exhibited potent in vitro fungicidal activities against a broad array of fungal pathogens including drug resistant strains. The 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with a C12 to C16 aliphatic side chain at C-6 has been shown to be the antifungal pharmacophore and may serve as a new antifungal template for further lead optimization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fcd5a4018ea0907eb0b664882ea593 https://doi.org/10.1021/ml200020h Zobrazit plný text záznamu