Yield of Screening Colonoscopy in First-degree Relatives of Patients With Serrated Polyposis Syndrome
| Autor: | Kristien M. A. J. Tytgat, Karam S. Boparai, Yark Hazewinkel, Susanne van Eeden, Paul Fockens, Theo A. M. van Os, Evelien Dekker, JJ Koornstra |
|---|---|
| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Human Genetics, Amsterdam Public Health, Pathology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male HYPERPLASTIC POLYPOSIS medicine.medical_specialty family Colorectal cancer serrated Colonoscopy colorectal cancer Gastroenterology COLORECTAL-CANCER Neoplasms Multiple Primary Interquartile range HIGH PREVALENCE Internal medicine MANAGEMENT Humans Medicine Prospective Studies First-degree relatives Sibling Prospective cohort study polyps Early Detection of Cancer Aged Family Health RISK medicine.diagnostic_test business.industry Middle Aged medicine.disease digestive system diseases Pedigree Adenomatous Polyposis Coli Hyperplastic Polyp Colonic Neoplasms Female business Sessile serrated adenoma |
| Zdroj: | Journal of clinical gastroenterology, 49(5), 407-412. LIPPINCOTT WILLIAMS & WILKINS Journal of clinical gastroenterology, 49(5), 407-412. Lippincott Williams and Wilkins |
| ISSN: | 0192-0790 |
| Popis: | Goals: We aimed to evaluate the diagnostic yield of screening colonoscopies in first-degree relatives (FDRs) of patients with serrated polyposis syndrome (SPS).Background: Patients with SPS are at an increased risk for colorectal cancer. Although inheritance patterns are unknown, FDRs of these patients have an increased risk for both colorectal cancer and SPS. Prospective studies evaluating the yield of screening colonoscopies in this group are however scarce. This information would be useful to evaluate a possible mode of inheritance and to investigate whether screening colonoscopies are justified in this group.Study: FDR of patients with SPS were invited to undergo colonoscopy. The diagnostic yield was expressed by the number of FDRs with at least 1 significant polyp relative to the total number of included FDRs. Significant polyps were defined adenomas, traditional serrated adenomas, sessile serrated adenoma/ polyp, or proximal hyperplastic polyp. Tissue specimens were reviewed by one expert pathologist.Results: Seventy-seven FDRs underwent colonoscopy (median age 52 y; interquartile range, 41 to 60). Colorectal cancer was not diagnosed. One or more significant polyps were detected in 43% of FDRs. No differences based on age, gender, or familial relationship were observed in the detection of polyps. Seven first-degree (9%) relatives had multiple polyps (>= 5). Eleven (14%) FDRs fulfilled SPS WHO-criterion 2, of whom 1 sibling also met SPS WHO-criterion 3.Conclusions: The yield of a single screening colonoscopy in FDRs of patients with serrated polyposis is substantial, warranting a colonoscopy screening program for these individuals. |
| Databáze: | OpenAIRE |
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