8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors
| Autor: | Irene Ruengkhachorn, Usanee Chatchotikawong, Nisarat Phithakwatchara, Chairat Leelaphatanadit |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Time Factors Adolescent Epidemiology medicine.medical_treatment Metastasis Tertiary Care Centers Young Adult Pregnancy Malignant Ovarian Germ Cell Tumor medicine Dysgerminoma Prevalence Humans Retroperitoneal Neoplasms Child Survival rate Neoplasm Staging Retrospective Studies Gynecology Ovarian Neoplasms business.industry Public Health Environmental and Occupational Health Pregnancy Outcome Neoplasms Germ Cell and Embryonal medicine.disease Endodermal sinus tumor Thailand Combined Modality Therapy Surgery Survival Rate Oncology Lymphatic Metastasis Disease Progression Lymph Node Excision Immature teratoma Lymphadenectomy Female Germ cell tumors Lymph Nodes business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(4) |
| ISSN: | 2476-762X |
| Popis: | Purpose To determine the rate of lymph node metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumor (MOGCT). Materials and methods Medical records of apparent early-stage MOGCT patients undergoing primary surgical treatment at Siriraj Hospital, Bangkok, Thailand, between January 2006 and December 2013, were retrospectively reviewed. Results Thirty-eight patients had apparent stage I-II MOGCT. The mean age was 22.1±7.7 years (median, 20.8 years; range, 7.7-35.6 years). The mean tumor size was 17.8±6.5 cm with a median of 20 (range 4-30) cm. Three most common histopathologies were dysgerminoma (12 patients, 31.6%), immature teratoma (12 patients, 31.6%), and endodermal sinus tumor (6 patients, 15.8%). Twenty-seven of 38 patients underwent lymphadenectomy; 13 patients (48.2%) were stage IA and 8 patients (29.6%) were stage IC. The rate of retroperitoneal nodes metastasis was 7.4% (2/27 patients). At 26.1 months of median follow-up time (range 1.9-88.5 months), 9 patients retained fertility functions, with uneventful pregnancies in 3 of these. Only one patient (2.6%) had progression of disease at 4.9 months after surgery. The 5-year survival rate was 97.4%. Conclusion As the rate of pelvic or para-aortic node metastasis in MOGCT is considerable, lymphadenectomy should be incorporated in surgical staging procedures. |
| Databáze: | OpenAIRE |
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