Mimicking mechanical response of natural tissues. Strain hardening induced by transient reticulation in lactose-modified chitosan (chitlac)
| Autor: | Andrea Travan, Davide Porrelli, Pasquale Sacco, Sergio Paoletti, Ivan Donati, Michela Cok, Eleonora Marsich, Massimiliano Borgogna |
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| Přispěvatelé: | Cok, Michela, Sacco, Pasquale, Porrelli, Davide, Travan, Andrea, Borgogna, Massimiliano, Marsich, Eleonora, Paoletti, Sergio, Donati, Ivan |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Dilatant
Magnetic Resonance Spectroscopy chemistry.chemical_element Biocompatible Materials Lactose 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Chitosan chemistry.chemical_compound Rheology Polyol Biomimetic Materials Structural Biology Borates ECM Lactose-modified chitosan Strain hardening Molecular Biology Humans Mechanotransduction Boron chemistry.chemical_classification Viscosity Borax General Medicine Strain hardening exponent 021001 nanoscience & nanotechnology Elasticity 0104 chemical sciences Cross-Linking Reagents chemistry Biophysics Stress Mechanical 0210 nano-technology |
| Popis: | The effect of transient cross-links has been explored on a lactose-modified chitosan, which previously had shown interesting biological features. The presence of galactose side chains and of the polyol spacer resulted particularly appealing for the reticulation by borate ions. The interaction between chitlac and borax was investigated by means of 11B NMR while rheology pointed to a marked non-linear behavior depending on the amount of borax added to the system. The presence of limited amount of cross-linking ion led to dilatant behavior when the steady flow curve was measured. In addition, strain stiffening was noticed on elastic response upon exceeding a critical stress, indicating a transient nature in the formation of the cross-links. The non-linear response of chitlac in the presence of borax compared surprisingly well with the one showed by proteins composing the natural ECM pointing at a possible role of mechanotransduction in the biological significance of the modified chitosan. |
| Databáze: | OpenAIRE |
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