Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension
| Autor: | Kazuo Komamura, Shozo Shigemoto, Koji Yoneda, Toshiaki Hanafusa, Yuko Tsujita Kuroda, Yoshiaki Katayama, Rie Tatsumi, Kunio Miyatake, Katsushi Mori |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Essential hypertension Left ventricular hypertrophy Severity of Illness Index Muscle hypertrophy Electrocardiography Internal medicine E-selectin Internal Medicine medicine Humans Aged Body surface area biology business.industry Cell adhesion molecule Angiotensin II Adhesion Middle Aged medicine.disease Endocrinology Carotid Arteries Echocardiography Hypertension biology.protein Female Hypertrophy Left Ventricular business E-Selectin Tunica Intima Biomarkers |
| Zdroj: | American journal of hypertension. 14(9 Pt 1) |
| ISSN: | 0895-7061 |
| Popis: | Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 80 outpatients with uncomplicated essential hypertension. Although the levels of E-selectin and sICAM-1 were similar between the patients with and without left ventricular (LV) hypertrophy, sVCAM-1 level was significantly elevated in the patients with LV hypertrophy (759.7 ± 154.6 ng/mL v 984.4 ± 240.6 ng/mL, P < .0001). The LV mass normalized to body surface area or height were significantly correlated with sVCAM-1 (r = 0.615, P < .0001 and r = 0.571, P < .0001, respectively). These results indicate that a soluble adhesion molecule is correlated with LV mass in uncomplicated essential hypertensive patients. |
| Databáze: | OpenAIRE |
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