Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition

Autor: Rauchmann, Boris Stephan, Schneider-Axmann, Thomas, Perneczky, Robert, Initiative, Alzheimer's Disease Neuroimaging
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Oncology
blood [tau Proteins]
medicine.medical_specialty
Tau pathology
Databases
Factual
Neurofilament light
tau Proteins
blood [Neurofilament Proteins]
03 medical and health sciences
Cognition
0302 clinical medicine
blood [Alzheimer Disease]
Neuroimaging
Alzheimer Disease
Neurofilament Proteins
Internal medicine
blood [Amyloid beta-Peptides]
medicine
Humans
Effects of sleep deprivation on cognitive performance
ddc:610
Neurodegeneration
Phosphorylation
diagnostic imaging [Brain]
030304 developmental biology
0303 health sciences
Amyloid beta-Peptides
blood [Biomarkers]
business.industry
physiology [Cognition]
Brain
Psychiatry and Mental health
metabolism [Brain]
Positron-Emission Tomography
Cohort
Biomarker (medicine)
Surgery
Neurology (clinical)
Analysis of variance
business
diagnostic imaging [Alzheimer Disease]
Biomarkers
030217 neurology & neurosurgery
Zdroj: Journal of neurology, neurosurgery, and psychiatry 92(12), 1289-1295 (2021). doi:10.1136/jnnp-2020-325537
Journal of Neurology, Neurosurgery, and Psychiatry
Popis: ObjectiveTo explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we studied a subsample of the Alzheimer’s disease (AD) neuroimaging cohort with longitudinal blood peptide assessments.MethodsEight hundred and sixty-five AD Neuroimaging Initiative participants were included. Using established AD cut-points for the cerebrospinal fluid concentrations of Aβ42, total-tau and p-tau181, subjects were classified according to the National Institute on Aging-Alzheimer’s Association research framework, grouping markers into those of Aβ deposition (A), tau pathology (T) and neurodegeneration (N). Analysis of variance was used to compare the plasma biomarker data between the ATN groups. The rate of change over time of p-tau181 and NfL was obtained from linear mixed effects models and compared between the ATN groups. Linear regression analysis was used to investigate the association of baseline plasma biomarker concentrations and rates of change with future PET tau and Aβ load and cognitive performance.ResultsP-tau181 and NfL plasma concentrations increased along the AD spectrum, but only NfL showed greater rates of change in AD patients versus controls. Cognitive performance was associated cross-sectionally with NfL in all subgroups, and with p-tau181 only in AD spectrum individuals. The baseline concentrations of both plasma markers predicted PET Aβ and tau load and cognitive performance. The rate of change of NfL predicted future PET tau and cognitive performance.ConclusionsP-tau and NfL behave differently within the same individuals over time and may therefore offer complementary diagnostic information.Trial registration numberNCT02854033, NCT01231971.
Databáze: OpenAIRE
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