The association of folate and depression: A meta-analysis
| Autor: | Neal M. Kingston, Ansley Bender, Kelsey E. Hagan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Funnel plot Adolescent Population Young Adult 03 medical and health sciences Folic Acid 0302 clinical medicine Internal medicine medicine Humans Child education Biological Psychiatry Depression (differential diagnoses) Aged Depressive Disorder education.field_of_study Depression Publication bias Middle Aged 030227 psychiatry Psychiatry and Mental health Study heterogeneity Meta-analysis Vitamin B Complex Etiology Antidepressant Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 95:9-18 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2017.07.019 |
| Popis: | Background Previous research suggested that folate levels play an important role in the etiology and course of depression. However, the literature has been inconsistent with regard to differences in folate level between individuals with and without depression. The present meta-analysis synthesized the results of previous studies to examine whether individuals with depression had lower levels of folate than individuals without depression. Methods Meta-analytic procedures were conducted in accordance with PRISMA guidelines. Studies evaluating folate levels in individuals with and without depression via red blood cell folate, serum folate, or dietary intake of folate methods were identified via PsycINFO and PubMed. Random-effects meta-analysis was conducted using Hedge's g, and moderation analysis was used for both folate measurement method and population type. Study heterogeneity was assessed with I2 and publication bias was qualitatively assessed via funnel plot and quantitatively assessed with the trim-and-fill method and Begg's adjusted rank test. Results We found a significant, small effect size, such that individuals with depression had lower folate levels than those without depression, Hedge's g = −0.24 (95% CI = −0.31, −0.16), p Conclusions Individuals with depression have lower serum levels of folate and dietary folate intake than individuals without depression. Given that previous literature suggested folate supplementation improved the efficacy of traditional antidepressant medications, future research on folate supplementation in depression is warranted and clinicians may wish to consider folate supplementation for patients with depression. |
| Databáze: | OpenAIRE |
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