Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection
| Autor: | Luce Sergent, Frédéric Gottrand, Emilie Caron, Alain Duhamel, Nana Bartke, Marie-Odile Husson, Jean-Luc Desseyn |
|---|---|
| Přispěvatelé: | Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Copalis [le Portel, France], Nutricia Research, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), The present study was funded by a ‘seaminaroil’ grant – a project supported by FUI (Fonds Unique Interministériel) aiming at adding value to unused fish by-products – and financially supported by Nutricia Research., Lille Inflammation Research International Center (LIRIC) - U995, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Lille Inflammation Research International Center - U 995 [LIRIC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pseudomonas aeruginosa infection MESH: Pseudomonas Infections/microbiology MESH: Random Allocation Medicine (miscellaneous) MESH: Fishes medicine.disease_cause MESH: Bacterial Load Cystic fibrosis [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract MESH: Pneumonia Bacterial/prevention & control MESH: Pseudomonas Infections/diet therapy Random Allocation chemistry.chemical_compound 0302 clinical medicine MESH: Lung/immunology [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Animals MESH: Pneumonia Bacterial/diet therapy Lung MESH: Pseudomonas Infections/immunology 0303 health sciences Nutrition and Dietetics MESH: Pseudomonas aeruginosa/isolation & purification Fishes MESH: Respiratory Mucosa/metabolism 3. Good health medicine.anatomical_structure Liver Neutrophil Infiltration 030220 oncology & carcinogenesis MESH: Permeability MESH: Survival Analysis Pseudomonas aeruginosa MESH: Pneumonia Bacterial/microbiology Cytokines Arachidonic acid lipids (amino acids peptides and proteins) MESH: Immunity Innate MESH: Liver/chemistry MESH: Pneumonia Bacterial/immunology medicine.symptom MESH: Lung/metabolism MESH: Respiratory Mucosa/microbiology Context (language use) Inflammation Respiratory Mucosa Biology Permeability Microbiology 03 medical and health sciences Fish Oils Immune system MESH: Mice Inbred C57BL Fatty Acids Omega-3 MESH: Pseudomonas Infections/prevention & control Pneumonia Bacterial medicine Animals Immunologic Factors Pseudomonas Infections MESH: Neutrophil Infiltration/immunology Immunity Mucosal 030304 developmental biology MESH: Lung/microbiology Bacterial Load Dietary Supplements Fatty Acids Omega-3 Immunity Innate Mucosal Mice Inbred C57BL Pneumonia Bacterial Survival Analysis Alkylglycerols n-3 Long-chain PUFA MESH: Fatty Acids Omega-3/therapeutic use MESH: Respiratory Mucosa/immunology MESH: Fish Oils/therapeutic use medicine.disease MESH: Pseudomonas aeruginosa/immunology Immunity Innate MESH: Male Mice Inbred C57BL chemistry MESH: Immunologic Factors/therapeutic use MESH: Immunity Mucosal MESH: Dietary Supplements MESH: Cytokines/metabolism [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2015, 113 (2), pp.191-199. ⟨10.1017/S0007114514003705⟩ British Journal of Nutrition, 2015, 113 (2), pp.191-199. ⟨10.1017/S0007114514003705⟩ |
| ISSN: | 0007-1145 1475-2662 |
| Popis: | Pseudomonas aeruginosais an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased arachidonic acid and decreased DHA concentrations, is known to play a critical role in chronic inflammation associated with bacterial infection. Other lipids, such as EPA and alkylglycerols, are also known to play a role in inflammation, particularly by stimulating the immune system, decreasing inflammation and inhibiting bacterial growth. In this context, the goal of the present study was to assess the effect of dietary DHA/EPA, in a 2:1 ratio, and alkylglycerols, as natural compounds extracted from oils of rays and chimeras, respectively, on the inflammatory reaction induced byP. aeruginosapulmonary infection in mice. To this end, mice were fed with a control diet or isolipidic, isoenergetic diets prepared with oils enriched in DHA/EPA (2:1) or alkylglycerols for 5 weeks before the induction of acuteP. aeruginosalung infection by endotracheal instillation. In our model, DHA/EPA (2:1) significantly improved the survival of mice after infection, which was associated with the acceleration of bacterial clearance and the resolution of inflammation leading to the improvement of pulmonary injuries. By contrast, alkylglycerols did not affect the outcomes ofP. aeruginosainfection. Our findings suggest that supplementation with ray oil enriched in DHA/EPA (2:1) can be considered as a preventive treatment for patients at risk forP. aeruginosainfection. |
| Databáze: | OpenAIRE |
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