Palladium Catalyzed [3+2] Cycloaddition of Vinyl Aziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines
| Autor: | Fabrizio Vetica, Stephen J. Bailey, Dieter Enders, Kari Rissanen, Suruchi Mahajan, Carolina von Essen, Mukesh Kumar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Ligand Organic Chemistry asymmetric synthesis Indane Enantioselective synthesis chemistry.chemical_element spriopyrrolidines 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis Cycloaddition 0104 chemical sciences 3-diones chemistry.chemical_compound chemistry aziridines insane-1 palladium catalysis insane-1 3-diones Phosphine Palladium |
| Popis: | A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities. |
| Databáze: | OpenAIRE |
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