Liver transplantation for hepatitis B virus: Decreasing indication and changing trends
| Autor: | Naglaa Allam, Sammy Saab, Nasser Al-Masri, Hamad Al Bahili, Safiyya Ali, Waleed Al-Hamoudi, Faisal Abaalkhail, Mohammed Al Sebayel, Hussien Elsiesy, Abdulrahman Bendahmash, Mohammed Al Sofayan, Dieter C. Broering |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty HBsAg Hepatitis B virus Cirrhosis Carcinoma Hepatocellular Time Factors medicine.medical_treatment Saudi Arabia Liver transplantation medicine.disease_cause Gastroenterology Antiviral Agents Recurrence Risk Factors Retrospective Study Internal medicine medicine Humans Retrospective Studies business.industry Liver Neoplasms virus diseases General Medicine Hepatitis C Hepatitis B Middle Aged Viral Load medicine.disease digestive system diseases Liver Transplantation Transplantation Treatment Outcome HBeAg Immunology Disease Progression Female Virus Activation business Biomarkers |
| Zdroj: | World journal of gastroenterology. 21(26) |
| ISSN: | 2219-2840 |
| Popis: | AIM: To evaluate the indication and outcome of hepatitis B virus (HBV)-related liver transplantation (LT) in the era of newer antiviral agents. METHODS: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research Center. These data included demographic, perioperative and long-term postoperative follow-up data including viral serological markers, HBV DNA, and repeated liver imaging. Between January 1990 and January 2012, 133 patients (106 males and 27 females) underwent LT for HBV-related cirrhosis at our center. All patients were followed up frequently during the first year following transplantation, according to our standard protocol; follow-up visits occurred every 3-6 mo thereafter. Breakthrough infection was defined as re-emergence of HBV-DNA or hepatitis B surface antigen (HBsAg) while on treatment. Five patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide analog. RESULTS: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo (range: 1-274). The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%, respectively. The following factors were associated with disease recurrence: younger age (44.3 ± 16.2 years vs 51.4 ± 9.9 years, P = 0.02), positive pretransplant hepatitis B e antigen (HBeAg) (60% vs 14%, P < 0.0001), detectable pretransplant HBV DNA (60% vs 27%, P = 0.03), positive posttransplant HBsAg (80% vs 4%, P < 0.0001) and positive posttransplant HBeAg (27% vs 1%, P < 0.0001). Forty-four (33%) patients had hepatocellular carcinoma (HCC). In the first (pre-2007) group, HBV was the second leading indication for LT after hepatitis C virus infection. A total of 64 transplants were performed, including 46 (72%) for decompensated HBV cirrhosis, 12 (19%) for decompensated cirrhosis complicated by HCC and 6 (10%) for compensated cirrhosis complicated by HCC. In the second group, nonalcoholic steatohepatitis surpassed HBV as the second leading indication for LT. A total of 69 HBV related transplants were performed, including 43 (62%) for decompensated HBV cirrhosis, 7 (10%) for decompensated cirrhosis complicated by HCC and 19 (27.5%) for compensated cirrhosis complicated by HCC. There was a significant (P = 0.007) increase in the number of transplants for compensated cirrhosis complicated by HCC. CONCLUSION: The use of potent anti-HBV agents has led to a changing trend in the indications for LT. HBV is currently the third leading indication for LT in this hyperendemic area. |
| Databáze: | OpenAIRE |
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